An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene



Status:Completed
Conditions:Lung Cancer, Cancer, Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:September 2009
End Date:January 2016

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Trial Summary
Trial Overview
Inclusion Criteria

Phase 3, Randomized, Open-Label Study Of The Efficacy And Safety Of PF-02341066 Versus Standard Of Care Chemotherapy (Pemetrexed Or Docetaxel) In Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Harboring A Translocation Or Inversion Event Involving The Anaplastic Lymphoma Kinase (ALK) Gene Locus

This is a Phase 3 trial comparing the safety and anti-tumor activity of PF-02341066 versus
pemetrexed or docetaxel in patients with advanced non-small cell lung cancer with specific
gene profile involving the ALK gene after failure of one previous chemotherapy regimen that
included one platinum drug.


Inclusion Criteria:

- histologically or cytologically proven diagnosis of non-small cell lung cancer

- positive for the ALK fusion gene (test provided by a central laboratory)

- must have had disease progression after only one prior chemotherapy and that regimen
but must have included one platinum drug

- tumors must be measurable

Exclusion Criteria:

- prior treatment with PF-02341066

- current treatment in another clinical trial
We found this trial at
115
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The University Of Texas
Houston, Texas 77030
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Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
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Cleveland Clinic
9500 Euclid Avenue
Cleveland, Ohio 44106
216.444.2200
Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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Memorial Cancer Institute
3700 Johnson Street
Hollywood, Florida 33021
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Cancer Research Center of Hawaii
701 Ilalo Street Suite 600
Honolulu, Hawaii 96813
808-586-3010
Cancer Research Center of Hawaii The University of Hawaii Cancer Center is the only National...
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Indiana University Hospital
550 University Boulevard
Indianapolis, Indiana 46202
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University of California at Los Angeles
Los Angeles, California 90095
310-825-4321
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
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Seattle Cancer Care Alliance
825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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H. Lee Moffitt Cancer Center & Research Institute
12902 USF Magnolia Dr
Tampa, Florida 33612
(888) 663-3488
H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
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The Emory Clinic
Atlanta, Georgia 30322
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Emory University Clinic
Atlanta, Georgia 30322
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Winship Cancer Institution
Atlanta, Georgia 30322
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Georgia Cancer Specialists - Administrative Annex
Atlanta, Georgia 30341
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Emory University Hospital Midtown
550 Peachtree St NE
Atlanta, Georgia 30308
(404) 686-4411
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Emory University Hospital
1364 Clifton Rd NE
Atlanta, Georgia 30322
(404) 712-2000
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Drug Shipment: University of Colorado Cancer Center, Anschutz Cancer Pavilion
Aurora, Colorado 80045
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University of Colorado Denver (CTRC)
Aurora, Colorado 80045
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Unviersity of Colorado Hospital, Anschutz Cancer Pavilion
Aurora, Colorado 80045
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Unviersity of Colorado Hospital, Anschutz Inpatient Pavilion
Aurora, Colorado 80045
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Comprehensive Blood and Cancer Center
Bakersfield, California 93309
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland 21231
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Tower Cancer Research Foundation
Beverly Hills, California 90211
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Tower Hematology Oncology Medical Group
Beverly Hills, California 90211
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Massachusette General Hospital
Boston, Massachusetts 02114
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Massachussetts General Hospital
Boston, Massachusetts 02114
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Beth Isreal Deaconess Medical Center
Boston, Massachusetts 02115
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Dana-Farber Cancer Institute
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
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DFCI/Pharmacy (Drug Shipment Only)
Boston, Massachusetts 02215
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Sydney Cancer Centre
Camperdown, New South Wales 2050
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UNC Health Care, NC Cancer Hospital Infusion/lnpatient Pharmacy (CHIP)
Chapel Hill, North Carolina 27514
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UNC Hospitals
Chapel Hill, North Carolina 27599
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Rush University Medical Center
1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
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University of Chicago Medical Center
5841 S Maryland Ave
Chicago, Illinois 60637
(773) 702-1000
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Ohio State University Hospital East
Columbus, Ohio 43205
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Ohio State University James Cancer Hospital and Solove Research Institute
Columbus, Ohio 43210
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James Care in Kenny
2650 Kenny Road
Columbus, Ohio 43221
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Siteman Cancer Center - West County
Creve Coeur, Missouri 63141
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Georgia Cancer Specialists - Stemmer
Decatur, Georgia 30033
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Kaiser Permanente
Denver, Colorado 80205
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Karmanos Cancer Institute
Detroit, Michigan 48201
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Tennessee Oncology, PLLC
Dickson, Tennessee 37055
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Vincent Armenio
East Providence, Rhode Island 02914
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Pharma Resource
East Providence, Rhode Island 02915
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Lawrence and Idell Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
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Tennessee Oncology, PLLC
Franklin, Tennessee 37067
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Tennessee Oncology, PLLC
Gallatin, Tennessee 37066
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Ingalls Memorial Hospital (Drug Shipment Only)
Harvey, Illinois 60426
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Monroe Medical Associates
Harvey, Illinois 60426
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Ingalls Memorial Hospital
1 Ingalls Dr
Harvey, Illinois 60426
(708) 333-2300
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Tennessee Oncology, PLLC
Hermitage, Tennessee 37076
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Penn State Milton S. Hershey Medical Center, Penn State Hershey Cancer Institute
Hershey, Pennsylvania 17033
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Hawaii Medical Center - East
2226 Liliha St
Honolulu, Hawaii 96817
(808) 547-6011
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OnCare Hawaii, Inc.
Honolulu, Hawaii 96813
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Ship drug to: Investigational Drug Services
Indianapolis, Indiana 46202
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Wishard Memorial Hospital
Indianapolis, Indiana 46202
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Springmill Medical Clinic
Indianapolis, Indiana 46290
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Indiana University Melvin and Bren Simon Cancer Center
535 Barnhill Dr
Indianapolis, Indiana 46202
(888) 600-4822
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UCSD Medical Center- La Jolla
La Jolla, California 92037
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Moores UC San Diego Cancer Center
La Jolla, California 92093
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Kaiser Permanente
Lafayette, Colorado 80026
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NSLIJ Health System/Monter Cancer Center
Lake Success, New York 11042
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Cancer Center of South Florida Foundation, Inc.
Lake Worth, Florida 33461
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Dartmouth Hitchcock Medical Center
1 Medical Center Dr
Lebanon, New Hampshire 03756
 (603) 650-5000
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Tennessee Oncology, PLLC
Lebanon, Tennessee 37087
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University of Arkansas for Medical Research, Winthrop Rockefeller Cancer Institute
Little Rock, Arkansas 72205
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Drug Shipping Address: [IRB# 10-001530] Ronald Reagan UCLA
Los Angeles, California 90095
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Ronald Reagan UCLA Medical Center
Los Angeles, California 90095
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Ucla Hematology/Oncology
Los Angeles, California 90095
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UCLA Ophthalmic Oncology Center
Los Angeles, California 90095
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Georgia Cancer Specialists - Macon
Macon, Georgia 31217
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Georgia Cancer Specialists - Kennestone
Marietta, Georgia 30060
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Monroe Medical Associates
Munster, Indiana 46321
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Community Hospital
Munster, Indiana 46321
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Tennessee Oncology, PLLC
Murfreesboro, Tennessee 37130
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Sarah Cannon Research Institute
3322 West End Avenue
Nashville, Tennessee 37203
(615)329-SCRI (7274)
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Tennessee Oncology, PLLC
250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
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Vanderbilt Cancer Clinic
Nashville, Tennessee 37232
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The Vanderbilt Chemo Pharmacy
Nashville, Tennessee 37232
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Drug Shipping for Yale; C/O Thomas Ferenez, RPh, BCOP
New Haven, Connecticut 06510
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Smilow Cancer Hospital of Yale New Haven
New Haven, Connecticut 06520
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Clinical Trial Office
New Haven, Connecticut 06519
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Yale Cancer Center
333 Cedar Street
New Haven, Connecticut 06520
(203) 785-4095
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Memorial Sloan-Kettering Cancer Center: Rockefeller Outpatient Pavillion
New York, New York 10022
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Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
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Department of Medicine MSG at SUNY HSC at Syracuse, INC., d/b/a University Physicians
Oneida, New York 13421
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Ship Drug To : Kevin Kong- University of California, Irvine-Pharmacy
Orange, California 92868
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University of California, Irvine Medical Center
101 The City Drive South
Orange, California 92868
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Oswego, New York 13126
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Stanford University Cancer Center
Palo Alto, California 94305
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Memorial Cancer Institute West
Pembroke Pines, Florida 33028
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Abramson Cancer Center of the University of Pennsylvania at Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania
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Penn Presbyterian Medical Center
Philadelphia, Pennsylvania
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Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
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University of Pittsburgh Medical Center-Shadyside
Pittsburgh, Pennsylvania 15232
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University of Pittsburgh Medical Center
200 Lothrop St
Pittsburgh, Pennsylvania 15213
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UC Davis Cancer Center
Sacramento, California 95817
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University of California, Davis Medical Center
2315 Stockton Blvd.
Sacramento, California 95817
(916) 734-2011
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UCSD Medical Center - Hillcrest
San Diego, California 92103
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Georgia Cancer Specialists
Sandy Springs, Georgia 30342
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