Prospective, Multi-Center Clinical Outcomes Study Evaluating the chronOS Strip Combined With Bone Marrow Aspirate

The use of the chronOS Strip eliminates the need for autologous bone graft harvesting from a
secondary surgical site, thus reducing donor site morbidity. The chronOS Strip, combined
with autogenous blood and/or bone marrow aspirate, or autograft such as may be obtained from
the posterior spinal elements, is intended to be used in the spine for posterolateral
fusion. Following placement into the bony void, chronOS Strip resorbs and is replaced with
bone during the healing process. The chronOS Strip has several handling advantages over
existing ceramic bone void fillers traditionally utilized in spine fusion surgery. It is
easily shaped to precisely fill the skeletal void and stays localized once placed. Further,
the implant can be rolled, folded, cut or sutured intra-operatively, and then conformed to
each patient's anatomy.

The chronOS Strip is available in various sizes and thicknesses. It is provided in a
sterile perfusion pack which, when connected to a standard syringe, can be used to perfuse
the chronOS Strip with the patient's blood and/or bone marrow aspirate.