Marijuana Drug Discrimination and Self-Administration
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 21 - 45 |
| Updated: | 4/21/2016 |
| Start Date: | April 2009 |
| End Date: | December 2014 |
Smoked Marijuana Discrimination and Marijuana Choice in Humans: A Laboratory Mode
This study is designed to investigate the associations among marijuana's discriminative
stimulus, reinforcing, subjective (e.g. craving) and physiological effects, and to assess
the relative ability of oral THC to block these effects.
stimulus, reinforcing, subjective (e.g. craving) and physiological effects, and to assess
the relative ability of oral THC to block these effects.
Volunteers will be asked to live on a research unit for up to twenty-six (26) consecutive
nights and will participate in a total of 38 study sessions held on 19 weekdays. Each
session will last approximately four hours and there will be two sessions per day, therefore
each study day will last approximately eight hours. In addition to these study sessions, an
orientation session will be conducted on the Friday prior to admission to the inpatient
unit, and a lottery session will be held on the last day of the study.
During each study session participants will be asked to smoke a cigarette. The cigarette may
contain marijuana or it may contain placebo (a blank). Participants will also be asked to
swallow a capsule 2-hours prior to smoking the cigarette. The capsule could contain placebo
(a blank), THC (delta-9 tetrahydrocannabinol, which is the active ingredient in marijuana
responsible for its mood effects), or d-amphetamine. We will have participants answer
questions about how the drugs make them feel and measure their vitals signs (blood pressure,
heart rate, and oxygen saturation) will be measured using a non-invasive (external) vitals
monitor.
nights and will participate in a total of 38 study sessions held on 19 weekdays. Each
session will last approximately four hours and there will be two sessions per day, therefore
each study day will last approximately eight hours. In addition to these study sessions, an
orientation session will be conducted on the Friday prior to admission to the inpatient
unit, and a lottery session will be held on the last day of the study.
During each study session participants will be asked to smoke a cigarette. The cigarette may
contain marijuana or it may contain placebo (a blank). Participants will also be asked to
swallow a capsule 2-hours prior to smoking the cigarette. The capsule could contain placebo
(a blank), THC (delta-9 tetrahydrocannabinol, which is the active ingredient in marijuana
responsible for its mood effects), or d-amphetamine. We will have participants answer
questions about how the drugs make them feel and measure their vitals signs (blood pressure,
heart rate, and oxygen saturation) will be measured using a non-invasive (external) vitals
monitor.
Inclusion Criteria:
- Female and male volunteers must be in generally good health (as indicated by results
from medical history, physical exam, electrocardiogram, urine and blood samples at
screening and upon arrival at the laboratory (urine samples only).
- Psychiatric examination must meet DSM-IV criteria for Cannabis Dependence.
- Individuals must be legally and mentally competent to provide written informed
consent.
- Those who are unable to give their voluntary informed consent will not be accepted.
Exclusion Criteria:
- Current serious Axis I disorder (except Cannabis or Nicotine Dependence), neurologic,
cardiovascular, pulmonary or systemic (e.g., renal, hepatic) disease; cognitive
impairment; pregnancy (urine test), lactation (self-report), or not using
(self-report) medically approved contraceptives.
- Applicants who express interest in treatment will not be accepted for study and will
be provided with a treatment referral.
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Wayne State University Founded in 1868, Wayne State University is a nationally recognized metropolitan research...
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