Relapse Prevention With Varenicline
| Status: | Archived |
|---|---|
| Conditions: | Smoking Cessation, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | October 2008 |
This study aims to determine if varenicline (Chantix®), currently used as a smoking
cessation aid, will decrease the likelihood of relapse to smoking following a programmed
lapse in the laboratory. The hypothesis is that varenicline will reduce the reinforcing
effects of smoking and will delay or prevent relapse compared to placebo.
In this study, we plan to use an experimental model of a lapse, in which volunteers smoke
two cigarettes after a brief period of (12-24 hours). The goals of this study are to assess
the impact of varenicline on the subjective and reinforcing effects of cigarettes, as well
as the latency to resume smoking (relapse) following the lapse exposure.
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