Study of MDX-1203 in Subjects With Advanced/Recurrent Clear Cell Renal Cell Carcinoma (ccRCC) or Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma (B-NHL)
| Status: | Archived |
|---|---|
| Conditions: | Cancer, Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | July 2009 |
| End Date: | August 2014 |
A Phase I, Multicenter, Open-Label, Dose-Escalation, Multidose Study of MDX-1203 in Subjects With Advanced/Recurrent Clear Cell Renal Cell Carcinoma or Relapsed/Refractory B-Cell Non Hodgkin's Lymphoma
The purpose of this study is to determine if MDX-1203 is safe for the treatment of renal
cell carcinoma or non-hodgkin's lymphoma.
Multicenter, open-label, dose-escalation, multidose study of MDX-1203, a fully human
monoclonal antibody drug conjugate targeting the CD70 transmembrane cell-surface protein
which is highly expressed in ccRCC and B-NHL. MDX-1203 is composed of a human anti-CD70
monoclonal antibody covalently linked to a prodrug form of a cytotoxic deoxyribonucleic acid
(DNA) minor-groove binding agent (MGBA).
The study will consist of 3 periods: Screening (up to 28 days), Treatment (up to 17 cycles
or 2 years), and Follow-up (up to 6 months).
We found this trial at
5
sites
University of Chicago One of the world's premier academic and research institutions, the University of...
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1500 E Medical Center Dr
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health Systems The University of Michigan is home to one of the...
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University of Maryland, Baltimore Welcome to the University of Maryland, Baltimore (UMB) founded in 1807...
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Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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