Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome
| Status: | Completed |
|---|---|
| Conditions: | Constipation, Irritable Bowel Syndrome (IBS) |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | August 2009 |
| End Date: | June 2013 |
Double-blind, Placebo Controlled Trial Comparing Neomycin to Rifaximin Plus Neomycin in the Treatment of Methane Positive Subjects With Constipation-predominant Irritable Bowel Syndrome
In this study the investigators aim to compare the efficacy of neomycin to a combination of
rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test.
This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in
Scottsdale, AZ and Dr. Satish Rao in Georgia Regents University in Augusta, GA.
rifaximin and neomycin in the treatment of C-IBS subjects with methane on their breath test.
This study will be conducted in collaboration with Dr. John DiBaise at the Mayo Clinic in
Scottsdale, AZ and Dr. Satish Rao in Georgia Regents University in Augusta, GA.
Inclusion Criteria:
- Rome III positive IBS subjects (18-75 years of age)
- Meet criteria for constipation predominant IBS symptoms including ≤ 3 complete
spontaneous bowel movements per week with hard or lumpy stools.
- Presence of detectable methane on single breath sample (≥ 3ppm).
- If subjects are ≥ 50 years old, a colonoscopy had to have been completed within the
past 5 years.
Exclusion Criteria:
- Subjects with history of intestinal surgery (except appendectomy or cholecystectomy)
- Recent antibiotic use (within the last 30 days)
- Subjects with known pelvic floor dysfunction
- Pregnancy
- Creatinine level > 1.4
- Poorly controlled/uncontrolled significant medical condition that would interfere
with study procedures
- Subjects with hearing loss and/or tinnitus
- History of bowel obstruction
- History of celiac disease
- History of inflammatory bowel disease
- Cirrhosis
- Diabetes
We found this trial at
2
sites
Georgia Health Sciences University Georgia Regents University, home of the Medical College of Georgia, is...
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Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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