Endoscopic Third Ventriculostomy (ETV) Versus Ventriculoperitoneal Shunting (VPS) for the Surgical Management of Normal Pressure Hydrocephalus



Status:Completed
Conditions:Cognitive Studies, Overactive Bladder, Women's Studies, Urology
Therapuetic Areas:Gastroenterology, Nephrology / Urology, Psychiatry / Psychology, Reproductive
Healthy:No
Age Range:Any
Updated:9/23/2012
Start Date:March 2009
End Date:January 2012
Contact:Daniele Rigamonti, MD, FACS
Email:dr@jhmi.edu
Phone:(410) 955-2259

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Trial Summary
Trial Overview
Inclusion Criteria

The purpose of this study is to test and compare the efficacy of Endoscopic Third
Ventriculostomy with shunting of Cerebrospinal fluid (CSF)for treatment for patients of
Normal pressure Hydrocephalus.


Normal pressure Hydrocephalus is a reversible disorder of cognition and gait
disorder.Currently the shunting of CSF is the recommended treatment of these patients. Even
though shunts are known to be beneficial treatment of Hydrocephalus they often need
treatment or revision for infection or malfunction. Endoscopic Third Ventriculostomy is a
treatment without complications of shunt and is known to benefit obstructive forms of
hydrocephalus.Few studies have also shown that it may be efficacious treatment Normal
pressure Hydrocephalus.

Inclusion Criteria:

- Age 50 to 72 years old

- Meet at least 2 of 3 Hakim and Adams diagnostic criterion for NPH (dementia, gait
instability and urinary incontinence)

- Ventriculomegaly defined by CT or MRI, Evans' index > 0.3

- Clinical improvement after 3 day trial of CSF drainage.

- MMSE>24

- Informed consent from patient
We found this trial at
1
site
Johns Hopkins Hospital
1800 Orleans St.
Baltimore, Maryland 21287
410-955-5000
Johns Hopkins Hospital Patients are the focus of everything we do at The Johns Hopkins...
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Baltimore, MD
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