Effect of Pimecrolimus Cream on Cathelicidin Levels in Subjects With Eczema
| Status: | Archived |
|---|---|
| Conditions: | Psoriasis, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | October 2009 |
A Three-week, Double-blind, Randomized Study to Evaluate the Effect of Pimecrolimus Cream 1% on Cathelicidin Expression in the Skin of Subjects With Atopic Dermatitis
The purpose of this study is to determine the effect of topical pimecrolimus on the immune
system by assessing the levels of antimicrobial peptides in the skin of patients with
eczema. It is hypothesized that pimecrolimus applied topically will repair the body's
immune system in patients with eczema by increasing antimicrobial peptides.
Patients with atopic dermatitis (AD) have higher rates of skin infections from viruses and
bacteria. They also have an impaired innate immune system. Antimicrobial peptides are a
component of the innate immune system which are decreased in atopics. In vitro,
pimecrolimus has demonstrated its ability to increase antimicrobial peptides. This study
will examine the ability of pimecrolimus to increase antimicrobial peptides in vivo in AD
patients. Thus, the study will yield a better understanding of the role of pimecrolimus in
regulating the immune system in atopics.
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San Francisco General Hospital San Francisco General Hospital and Trauma Center (SFGH) is an essential...
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