Burden of Obstructive Sleep Apnea in Stroke (BOSAST)
| Status: | Terminated |
|---|---|
| Conditions: | Insomnia Sleep Studies, Neurology, Pulmonary |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 45 - 85 |
| Updated: | 4/21/2016 |
| Start Date: | August 2009 |
| End Date: | June 2011 |
There are two purposes of this study. The first purpose is to define the frequency of
obstructive sleep apnea in stroke survivors as well as its association with fatigue and
quality of life. The second purpose is to determine if continuous positive airways pressure
(CPAP) treatment can have a beneficial effect on these patients' fatigue and quality of
life.
obstructive sleep apnea in stroke survivors as well as its association with fatigue and
quality of life. The second purpose is to determine if continuous positive airways pressure
(CPAP) treatment can have a beneficial effect on these patients' fatigue and quality of
life.
Stroke survivors frequently complain of fatigue, depressive symptoms, and decreased
cognitive functioning. These burdens complicate the recovery and rehabilitation from stroke.
While there may be many contributing factors to these burdens, one factor in particular may
be both terribly common and yet readily susceptible to intervention. Consistent reports from
around the world demonstrate that >50% of stroke patients have obstructive sleep apnea
(OSA), a disorder that is also associated with fatigue, depressive symptoms, and decreased
cognitive functioning. OSA is also associated with increases in inflammatory products which
themselves are associated with the same array of burdens.
This study will examine inpatients at a stroke rehabilitation center. Patients' sleep will
be studied. Patients with OSA will be randomized to 10 days treatment double blind with
either continuous positive airways pressure (CPAP) treatment or to sub-therapeutic CPAP
treatment. After 10 days of treatment, the OSA patients and the stroke patient without OSA
will be restudied.
The study will shed light on the impact of OSA on stroke patients' burdens.
cognitive functioning. These burdens complicate the recovery and rehabilitation from stroke.
While there may be many contributing factors to these burdens, one factor in particular may
be both terribly common and yet readily susceptible to intervention. Consistent reports from
around the world demonstrate that >50% of stroke patients have obstructive sleep apnea
(OSA), a disorder that is also associated with fatigue, depressive symptoms, and decreased
cognitive functioning. OSA is also associated with increases in inflammatory products which
themselves are associated with the same array of burdens.
This study will examine inpatients at a stroke rehabilitation center. Patients' sleep will
be studied. Patients with OSA will be randomized to 10 days treatment double blind with
either continuous positive airways pressure (CPAP) treatment or to sub-therapeutic CPAP
treatment. After 10 days of treatment, the OSA patients and the stroke patient without OSA
will be restudied.
The study will shed light on the impact of OSA on stroke patients' burdens.
Inclusion Criteria:
- stroke survivor in stroke rehabilitation unit
- age 45-85
- able to consent
- no prior treatment with CPAP
Exclusion Criteria:
- complex apnea
- known inflammatory disease
- neurological disease precluding patient's ability to consent and cooperate
We found this trial at
1
site
