Microbial Community Composition and Metabolism in Cystic Fibrosis

Scientist have begun to realize that many types of bacteria often live together as a complex
community, and the investigators wish to apply that idea to the bacteria in the respiratory
system of people with Cystic Fibrosis (CF). It is possible that the survival of the many
millions of bacteria in the CF lung depends on the production of special chemicals that
might be made only by very few types of bacteria. If that is true, medicines that interfere
with those chemicals could treat the lung infections that cause trouble for nearly all
people with CF. The investigators wish to study the production of several potentially
critical chemicals by the respiratory bacteria and to examine the effect of those chemicals
on the makeup of the entire community of bacteria. To detect all the bacteria in that
community, the investigators will use new methods that use bacterial genetic information and
can detect hundreds of different types of bacteria in respiratory samples of individual CF
patients.