Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance
| Status: | Archived |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | August 2009 |
| End Date: | December 2010 |
Physical Inactivity and Insulin Resistance in Skeletal Muscle
The overall aim of the project is to determine whether or not exercise influences
cardiovascular or nervous responses to meal ingestion in individuals with insulin resistance
or type 2 diabetes.
Participants will undergo a screening procedure, including telephone screening and physical
examination, as well as determination of body composition and fitness. Participants will be
asked to complete 5-10 days of supervised exercise training and will undergo testing to
assess cardiovascular and metabolic responses to an oral glucose tolerance test, including
muscle sympathetic nerve activity, blood flow, and circulating glucose and insulin
concentrations at baseline and following training. In addition, day-to-day variations in
blood glucose will also be monitored. The overall aim of the project is to determine whether
or not acute exercise training influences postprandial metabolic, vascular or autonomic
nervous system responses in individuals with insulin resistance or T2D.
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