Evaluation of Intra-operative Ultrasound Contrast Enhancement in the Evaluation of Liver Tumors

The primary objective of this study is to demonstrate the safety of the use of
intra-operative ultrasound contrast (Definity®) administration. The secondary objective of
this study is to demonstrate the improved image quality and conspicuity of known liver
tumors using contrast enhancement.

Inclusion Criteria:

1. Undergoing a hepatic resection or hepatic ablation of pre-operative visualized liver
tumor:

2. ≥ 18 years of age

3. If female of child-bearing potential, negative pregnancy test within 14 days prior to
surgery

4. If subject is a sexually active male or a sexually active female of child-bearing
potential, subject agrees to use a medically accepted form of contraception from the
time of enrollment to completion of all follow-up study visits.

5. IRB-approved informed consent, signed by the subject or the subject's legally
authorized representative. ≥ 18 years of age

Exclusion Criteria:

1. Not a suitable candidate for operation