Does Small Intestinal Bacterial Overgrowth Contribute to Functional Dyspepsia
| Status: | Recruiting |
|---|---|
| Conditions: | Gastroesophageal Reflux Disease , Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 10/21/2012 |
| Start Date: | August 2007 |
| Contact: | Lisa R Fowles, BS |
| Email: | LFowles@salud.unm.edu |
| Phone: | 505-265-1711 |
The prevalence of functional dyspepsia (FD) is estimated to be 15% of the adult population.
FD is commonly described as a condition of chronic abdominal discomfort localized to the
upper abdomen. Postprandial bloating, pain, nausea, vomiting, belching, and early satiety
are common symptoms of the FD patient. FD is defined by >12 weeks of symptoms, which need
not be consecutive, within the preceding year consisting of a) persistent or recurrent
dyspepsia and b) an absence of organic disease after a gastrointestinal endoscopy or x-ray
series. FD is therefore considered a disorder of function because no mucosal pathology is
seen in these patients, as in patients with other functional disorders such as irritable
bowel syndrome (IBS) and fibromyalgia (FM). There is a remarkable degree of overlap among
these three disorders. These 3 disorders share the finding of hypersensitivity and the
symptom of postprandial bloating to suggest the possibility of a common origin.
Inclusion Criteria:
- Must have FD based on the most recent Umbrella criteria of one or more of: a.
bothersome postprandial fullness, b. early satiation, c. epigastric pain, d.
epigastric burning
- No evidence of organic disease (including H. pylori detected at time of endoscopy)
that is likely to explain the symptoms
- Criteria must be fulfilled for the last 3 months with symptom onset at least 6 months
before the diagnosis
- The physical exam, routine blood tests including CBC, chemistry panel and liver
tests, upper gastrointestinal endoscopy and 24h pH study must be normal
Exclusion Criteria:
- History of IBS,rheumatoid arthritis,H. Pylori infection,lupus,peptic ulcer,
cirrhosis,diabetes, HIV or TB
- Inflammatory bowel disease
- Bowel Resection (including gastric, small bowel or colon; gallbladder surgery or
appendectomy are NOT exclusion criteria)
- Anti/pro-biotics last 3 months
- Previous LBT (Lactulose Breath Test)
- Narcotic Dependence
- Pregnancy
- Control subjects will be excluded if they have symptoms of heartburn, retrosternal
chest pain, chronic cough, nausea or regurgitation suggestive of gastroesophageal
reflux disease
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