Treatment of Cocaine Dependence With Lisdexamfetamine

This 2-group, double-blind, placebo-controlled, 14-week study (N=100) will investigate the
efficacy of cognitive behavioral therapy plus lisdexamfetamine vs. placebo to treat cocaine
dependence. We hypothesize that lisdexamfetamine will reduce cocaine use (primary outcome),
as well as cocaine craving and impulsivity (secondary outcomes) vs. placebo.

Inclusion Criteria:

- Eligible participants must:

1. Be treatment-seeking males or females between 18 and 65 years-of-age;

2. Understand the study procedures and provide written informed consent;

3. Be judged by the examining physician to be in generally good health with the
exception of health problems related to acute drug use;

4. Meet DSM-IV criteria for cocaine-dependence.

Exclusion Criteria:

- Exclusion criteria include:

1. DSM-IV diagnoses for current psychotic disorders, mood disorders (except
substance-induced depression), anxiety disorders, ADHD, and other current
substance dependence (except marijuana and nicotine dependence); subjects may
not have physiological dependence upon alcohol requiring medical detoxification;

2. Current use of any prescription medications;

3. Females currently pregnant or nursing;

4. Current elevation of liver enzyme levels above twice normal limits;

5. Existing cardiovascular disease as determined by physician, EKG evaluation;

6. History of significant acute or chronic physical illness precluding
participation;

7. History of hyperthyroidism, glaucoma, or seizures.