Preoperative Chemotherapy and Bevacizumab in Patients With Stage IB (>4 cm), II, or Select Stage III NSCLC



Status:Archived
Conditions:Lung Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:August 2009
End Date:February 2014

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Phase II Trial of Preoperative Chemotherapy and Bevacizumab in Patients With Stage IB (>4 cm), II, or Select Stage III Non-Small Cell Lung Cancer


The rationale for this multicenter, phase II trial is to examine the impact of
carboplatin/paclitaxel with bevacizumab in the preoperative treatment of patients with stage
IB (> 4.0 cm), II, and select stage III NSCLC. If this novel regimen proves to be safe and
active in this setting, this would provide rationale for further investigation in a larger,
prospective, randomized setting.


Adjuvant chemotherapy for patients with completely resected stage II and select stage III
NSCLC is considered standard therapy. At least three large, prospective randomized trials
have proven the benefit of adjuvant chemotherapy in improving survival in these patients
(with a magnitude of benefit ranging from 4-12%). However, in patients who are not
considered to be candidates for up-front complete resection, preoperative therapy may be
indicated. Many of these patients will subsequently be eligible for resection (bimodality
therapy). The rationale for this multicenter, Phase II trial is to examine the impact of
carboplatin/paclitaxel with bevacizumab in the preoperative treatment of patients with stage
IB (>4.0 cm), II, and select stage III NSCLC. This trial will be conducted by the Sarah
Cannon Research Institute Oncology Research Consortium. If this novel regimen proves to be
safe and active in this setting, this would provide rationale for further investigation in a
larger, prospective, randomized setting.


We found this trial at
6
sites
Grand Rapids, Michigan 49503
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Grand Rapids, MI
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4725 North Federal Highway
Fort Lauderdale, Florida 33308
(954) 771-8000
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
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Fort Lauderdale, FL
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Louisville, Kentucky 40207
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Louisville, KY
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250 25th Ave N, Ste 100
Nashville, Tennessee 37023
615-320-5090
Tennessee Oncology, PLLC Since 1976 Tennessee Oncology has been providing quality cancer care. In 2013,...
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Nashville, TN
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Portsmouth, New Hampshire 03801
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Portsmouth, NH
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Terre Haute, Indiana 47802
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mi
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Terre Haute, IN
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