Lipoic Acid to Treat Chronic Inflammatory Demyelinating Polyneuropathy

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a progressive disease leading to
paralysis. CIDP is an immune-mediated disorder resulting from a synergistic interaction of
T cell-mediated and B cell-mediated immune responses directed against peripheral nerve
antigens. These immune mediated responses in turn increase the production of reactive
oxygen intermediate and cause oxidative damage of the peripheral nerve system. Although
corticosteroids, plasma exchange, and intravenous immunoglobulin (IVIg) reduce impairment
caused by CIDP at least temporarily and can be used as a first-line treatments, they are not
ideal for long-term treatment because of serious side effects and cost. Alpha lipoic acid
(LA) is an antioxidant that also possesses anti-immune activity. It is effective in
treating diabetic neuropathy. It is also promising in treating patients with multiple
sclerosis.

Inclusion Criteria:

- diagnosis of CIDP

- on a stable dose of immunotherapy for at least 3 months before enrolling in the study

Exclusion Criteria:

- myelopathy or evidence of central demyelination

- persistent neurological deficits from stroke, CNS trauma, or peripheral neuropathy
from other causes (eg, diabetes mellitus, IgM, paraproteinaemia, or uraemic, toxic,
or familial neuropathy)

- evidence of systemic disease that might cause neuropathy

- heart diseases (congestive heart failure or arrhythmia)

- pulmonary conditions (asthma or CIPD)

- rheumatoid conditions (such as rheumatoid arthritis)

- renal failure