Exercise Dose-Response Effects in Prediabetes
| Status: | Completed |
|---|---|
| Conditions: | Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 45 - 75 |
| Updated: | 11/30/-0001 |
| Start Date: | July 2009 |
| End Date: | April 2014 |
| Contact: | Lori A Bateman, MS |
| Email: | lori.bateman@duke.edu |
| Phone: | 919-660-6785 |
Exercise Dose-Response Effects in Prediabetes: Responses and Mechanisms
The purpose of the study is to evaluate the effects of different amounts and intensities of
aerobic exercise training programs, with and without weight loss, in people who are at risk
for diabetes. An additional purpose of the study is to evaluate the factors in the blood
and in exercising muscles that contribute to the improvement in those risk factors. This
information will be used to improve exercise training guidelines for improving
cardiovascular and metabolic health in people with abnormal fasting glucose, also known as
prediabetes.
Inclusion Criteria:
- Age: 45-75 years
- Moderately Overweight determined by Body Mass Index: 25.0 - 35.4
- Fasting plasma glucose: > 95 - < 126 mg/dL
o Readings from two separate days, both being > 95 and one of the two being < 126
- Low density (LDL) cholesterol: < 190 mg/dL
- Triglycerides: < 600 mg/dL
- Resting blood pressure: < 160/90 mmHg
- Inactive: Exercise < one day/week; Peak oxygen use: > 18.0 - < 40.0 ml/kg/min
- Medications: Stable use of all medications for > three months
Exclusion Criteria:
- Smoker: Tobacco use within the last 12 months
- Dieting or intending to diet
- Use of potential confounding medications, e.g. Niacin containing drugs
- History of diabetes, heart disease or taking medication for those conditions
- History of hypertension (high blood pressure) not controlled with medication
- Pregnant or intending to become pregnant
- Unwillingness to undergo a three month control/run-in period, be randomized to any
one of four intervention groups, submit to thigh muscle biopsies and all other study
testing or continuously participate in a randomly assigned exercise training or
lifestyle intervention program for six months
- Orthopedic limitations, musculoskeletal disease and/or injury
- Allergic to xylocaine (anesthetic or numbing medicine)
- Inability to give blood continuously through a catheter (please notify the study
nurse of any difficulty you have experienced in the past when having your blood
drawn; the study nurse will determine whether you are excluded for this reason)
- Unwillingness to exercise at least twice per week at the Duke Center for Living
Health and Fitness Center during research study staff supervised times
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