Study Of PHarmacogenetics in Ethnically Diverse Populations (SOPHIE Study)
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 5/16/2018 |
| Start Date: | February 2004 |
| End Date: | December 2021 |
Collect DNA from well-characterized healthy volunteers.
DNA and plasma will be used to identify and determine allele frequencies of genetic variants
in membrane transporters and other genes relevant to human disease or drug response,
including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease,
asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve
as the hypothesis-generating phase for future studies by identifying genetic variants and
determining allele frequencies among an ethnically diverse cohort of healthy volunteers.
Future investigations (separate IRB applications) will attempt to correlate genotypes to
phenotypes among this cohort of volunteers. The allele identification and frequency data from
this group of healthy volunteers will also be used to design association studies in relevant
disease populations.
Determine if identified sequence variants are associated with gain or loss of in vitro
biologic function using lymphocytes obtained from patients.
in membrane transporters and other genes relevant to human disease or drug response,
including drug metabolizing enzymes, collagen, race/ethnicity, neurovascular disease,
asthma/allergy/lung disease, and cardiovascular disease. This phase of the study will serve
as the hypothesis-generating phase for future studies by identifying genetic variants and
determining allele frequencies among an ethnically diverse cohort of healthy volunteers.
Future investigations (separate IRB applications) will attempt to correlate genotypes to
phenotypes among this cohort of volunteers. The allele identification and frequency data from
this group of healthy volunteers will also be used to design association studies in relevant
disease populations.
Determine if identified sequence variants are associated with gain or loss of in vitro
biologic function using lymphocytes obtained from patients.
Inclusion Criteria:
- Healthy adult subjects of both genders and specified ethnic groups
- Subjects must be between 18-40 years of age
Exclusion Criteria:
- Smokers
- Drink > 2 alcoholic beverages/day
- Take any chronic medication
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