MRI Laryngeal Imaging With a Surface Coil
| Status: | Terminated |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/7/2017 |
| Start Date: | July 2009 |
| End Date: | January 2010 |
High Resolution MRI in the Evaluation of Laryngeal Neoplasia
To determine if high resolution MRI can detect early invasion of cartilage by laryngeal
carcinoma, and to determine if high resolution MRI may be superior to conventional MRI
imaging or CT imaging to detect cartilage invasion.
carcinoma, and to determine if high resolution MRI may be superior to conventional MRI
imaging or CT imaging to detect cartilage invasion.
The purpose of this study is to use a new MRI imaging coil developed for enhancing structures
made of cartilage to determine if the device can produce improved images of the human larynx.
In addition, if enhanced images can be obtained, a further purpose will be to determine if,
in patients with laryngeal cancer, whether or not early invasion of cartilage can be
detected. Patients with laryngeal cancer will be asked to undergone an MRI scan using this
new image-enhancing coil to see if cartilage invasion can be detected. Patients will be
followed during and after treatment to determine their ultimate response to treatment. No
additional MRI scans for the purposes of this protocol will be performed other than the
initial pretreatment scan.
We hope to determine if this new MRI imaging device can detect early cancer invasion of the
laryngeal cartilages in patients with laryngeal cancer. Since this modality has never been
attempted before on the human larynx, we are simply looking for the presence or absence of
cartilage destruction. Both conventional CT and conventional MRI are poor at recongnizing
this finding. High resolution MRI may allow the detection of this finding or it may not -
detection of this finding is the endpoint.
made of cartilage to determine if the device can produce improved images of the human larynx.
In addition, if enhanced images can be obtained, a further purpose will be to determine if,
in patients with laryngeal cancer, whether or not early invasion of cartilage can be
detected. Patients with laryngeal cancer will be asked to undergone an MRI scan using this
new image-enhancing coil to see if cartilage invasion can be detected. Patients will be
followed during and after treatment to determine their ultimate response to treatment. No
additional MRI scans for the purposes of this protocol will be performed other than the
initial pretreatment scan.
We hope to determine if this new MRI imaging device can detect early cancer invasion of the
laryngeal cartilages in patients with laryngeal cancer. Since this modality has never been
attempted before on the human larynx, we are simply looking for the presence or absence of
cartilage destruction. Both conventional CT and conventional MRI are poor at recongnizing
this finding. High resolution MRI may allow the detection of this finding or it may not -
detection of this finding is the endpoint.
Inclusion Criteria:
- Patients with benign or malignant neoplasm of the larynx.
- Patients who have undergone prior surgery, radiation therapy, or chemotherapy for
cancer of the laryngopharynx will be eligible to participate.
- Patients 18 years of age and older at time of evaluation, male and female, all
ethnicities.
- Ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria:
- Pregnancy
- Claustrophobia.
- Anatomic parameters which preclude scanning, such as limited range of neck motion, or
inability to remain flat for at least 15 minutes.
- Patients with implanted devices (eg, defibrillator, pacemaker) that are a known
contraindication to magnetic resonance imaging.
- Allergy to gadolinium contrast.
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Stanford University School of Medicine Vast in both its physical scale and its impact on...
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