Impact of Genetics on Metformin Pharmacokinetics
| Status: | Archived |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
Specific Aims: To compare metformin pharmacokinetics in monozygotic and dizygotic twin
pairs. Comparing renal clearance of metformin in monozygotic and dizygotic twins will allow
us to better understand the influence of heredity on variation in renal elimination.
Furthermore, genotyping renal transporter genes in monozygotic and dizygotic twin pairs with
significant differences in renal clearance of metformin may give us insight into the genes
responsible for this variability.
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