Tolerability and Lipid Lowering Effect of Weekly/Biweekly Crestor in Statin Intolerant Patients Treated With Zetia



Status:Completed
Conditions:High Cholesterol
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:4/2/2016
Start Date:September 2009
End Date:March 2011

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Trial Summary
Trial Overview
Inclusion Criteria

Recently, research studies have shown that patients who have had trouble taking statins
every day, are able to take statins if they take them only once or twice a week. The
investigators are doing a research study which involves switching people who are taking
ezetimibe to the statin Crestor once or twice a week and to see how ell Crestor lowers
cholesterol and if it is tolerated.


Inclusion Criteria:

- Patients with a history of intolerance to statins

- Patients currently receiving ezetimibe

- Patients willing and able to provide signed informed consent

Exclusion Criteria:

- Patients receiving a statin (Lipitor, Crestor, Lescol, Simvastatin, or Pravachol)

- Stroke, TIA, myocardial infarction, unstable angina, percutaneous coronary
intervention, coronary artery bypass surgery, or major surgery within 3 months

- Cancer undergoing active treatment

- Creatinine clearance < 40 ml/minute

- Active liver disease or persistent elevation of SGOT or SGPT > 2 times the upper
limit of normal level

- Participation in any clinical study within the last 30 days

- Drug addition or alcohol abuse within the past 6 months

- Use of cyclosporine within the last 3 months

- Use of gemfibrozil within the last month

- Patients unwilling or unable to provide informed consent

- Patients with poor compliance

- Women of childbearing potential

- History of rhabdomyolysis due to statins
We found this trial at
1
site
Bronx VA Medical Center
Bronx, New York 10468
?
mi
from
Bronx, NY
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