Therapeutic Angiotensin-(1-7) in Treating Patients With Sarcoma That is Metastatic or Cannot Be Removed by Surgery
| Status: | Archived |
|---|---|
| Conditions: | Ovarian Cancer, Cancer, Cancer, Kidney Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | October 2009 |
A Phase II Clinical Trial of Angiotensin 1-7 For the Second or Third Line Treatment of Patients With Metastatic or Unresectable Sarcomas
RATIONALE: Therapeutic angiotensin-(1-7) may stop the growth of sarcoma by blocking blood
flow to the tumor.
PURPOSE: This phase II trial is studying the side effects of therapeutic angiotensin-(1-7)
and to see how well it works as second-line therapy or third-line therapy in treating
patients with sarcoma that is metastatic or that cannot be removed by surgery.
OBJECTIVES:
Primary
- To evaluate the response rate in patients with chemotherapy-refractory, metastatic or
unresectable sarcoma treated with therapeutic angiotensin-(1-7).
- To evaluate toxicities associated with this treatment in these patients.
Secondary
- To assess time to progression and overall survival of patients treated with therapeutic
angiotensin-(1-7).
- To evaluate accumulation of therapeutic angiotensin-(1-7) after 21 days of continuous
treatment and quantify changes in plasma levels of angiogenic peptides including
placental-growth factor.
OUTLINE: Patients receive therapeutic angiotensin-(1-7) subcutaneously once daily. Treatment
continues daily in the absence of disease progression or unacceptable toxicity.
Blood samples are collected periodically for pharmacokinetic and other biomarker analyses.
After completion of study treatment, patients are followed up every 3 months for 2 years,
every 6 months for 3 years, and then annually thereafter.
We found this trial at
1
site
1 Medical Center Blvd
Winston-Salem, North Carolina 27103
Winston-Salem, North Carolina 27103
(336) 716-2011
Wake Forest University Baptist Medical Center Welcome to Wake Forest Baptist Medical Center, a fully...
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