Effects of Gastric Antral Botulinum Toxin Injections in Obese Subjects



Status:Archived
Conditions:Obesity Weight Loss, Gastrointestinal
Therapuetic Areas:Endocrinology, Gastroenterology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:September 2009
End Date:June 2011

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Physiologic Effects of High-Dose Gastric Antral Botulinum Toxin Injections


Obesity is an important public health problem in the United States. The investigators
hypothesize that stomach injections of botulinum toxin A (BTA), delivered through an
endoscope using endoscopic ultrasound (EUS), may cause delayed gastric emptying, satiation,
and reduction in body weight. This protocol is designed to study the effects and safety of
gastric BTA injections. Subjects are randomized to receive placebo or one of two different
doses of BTA injected into the stomach during one endoscopy, performed via the mouth.
Gastric emptying, satiation, symptoms, psychological dimensions of eating behavior, and
caloric intake are recorded before and after injections, and subjects are seen in follow-up
for 24 weeks.



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