Genetic Testing in Predicting Biomarkers of Recurrence in Patients With Prostate Cancer Undergoing Surgery
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 12/21/2018 |
| Start Date: | November 26, 2007 |
| End Date: | September 2019 |
Pre-Surgical EPS Biomarkers as Predictors of Biochemical Recurrence
This trial studies the side effects and best way to perform genetic testing in predicting
biomarkers of recurrence in patients with prostate cancer undergoing surgery. Collecting and
storing samples of tissue, blood, and other body fluids from patients to test in the
laboratory and collecting information about the patient's health and treatment may help
doctors learn more about cancer and help predict the recurrence of prostate cancer
biomarkers of recurrence in patients with prostate cancer undergoing surgery. Collecting and
storing samples of tissue, blood, and other body fluids from patients to test in the
laboratory and collecting information about the patient's health and treatment may help
doctors learn more about cancer and help predict the recurrence of prostate cancer
PRIMARY OBJECTIVES: I. To explore the performance of these models in predicting the
likelihood of biochemical recurrence (BCR).
SECONDARY OBJECTIVES: I. To explore the performance of these models in predicting upgrading
and upstaging prior to surgery. II. To explore the performance of these models in improving
risk stratification among patients eligible for active surveillance. III. To determine
whether prostatic massage or surgery raises the count of circulating tumor cells (CTC) in
post-digital rectal exam (DRE) blood specimens.
OUTLINE: Patients receive prostatic massage and undergo a digital rectal exam (DRE).
Laboratory assessments are performed and blood samples are collected for molecular biology
testing. On the day of the scheduled prostatectomy, a second blood collection is performed
prior to surgery.
likelihood of biochemical recurrence (BCR).
SECONDARY OBJECTIVES: I. To explore the performance of these models in predicting upgrading
and upstaging prior to surgery. II. To explore the performance of these models in improving
risk stratification among patients eligible for active surveillance. III. To determine
whether prostatic massage or surgery raises the count of circulating tumor cells (CTC) in
post-digital rectal exam (DRE) blood specimens.
OUTLINE: Patients receive prostatic massage and undergo a digital rectal exam (DRE).
Laboratory assessments are performed and blood samples are collected for molecular biology
testing. On the day of the scheduled prostatectomy, a second blood collection is performed
prior to surgery.
Inclusion Criteria:
- All men undergoing robotic prostatectomy or cystoprostatectomy at City of Hope will be
eligible for the study
Exclusion Criteria:
- Men who undergo neoadjuvant treatment with Androgen Deprivation Therapy (ADT) or salvage
prostatectomy including those who have had brachytherapy will be excluded
We found this trial at
1
site
Duarte, California 91010
Principal Investigator: Steven Smith, PhD
Phone: 800-826-4673
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