Glucose Homeostasis Pre and Post Bariatric Surgery
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 70 |
| Updated: | 8/12/2018 |
| Start Date: | December 2009 |
| End Date: | June 2018 |
Effect of Bariatric Surgery-induced Weight Loss on Glucose Homeostasis
The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y
gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the
clinical trial. If your insurance does not cover the procedure, then you are responsible for
payment of the surgical process. We are doing pre and post surgery testing to provide a
better understanding of the effect of bariatric surgery-induced weight loss on metabolic
function.
gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the
clinical trial. If your insurance does not cover the procedure, then you are responsible for
payment of the surgical process. We are doing pre and post surgery testing to provide a
better understanding of the effect of bariatric surgery-induced weight loss on metabolic
function.
Bariatric surgery is the most effective weight loss therapy for obesity. Moreover, the early
improvement in insulin sensitivity and the resolution of type 2 diabetes after bariatric
surgery has led to the hypothesis that bariatric surgery has specific beneficial effects on
glucose homeostasis beyond weight loss alone. However, this hypothesis has never been
adequately evaluated in human subjects. Therefore, the primary goal of this proposal is to
provide a better understanding of the effect of bariatric surgery-induced weight loss on
insulin action and pancreatic beta cell function.
improvement in insulin sensitivity and the resolution of type 2 diabetes after bariatric
surgery has led to the hypothesis that bariatric surgery has specific beneficial effects on
glucose homeostasis beyond weight loss alone. However, this hypothesis has never been
adequately evaluated in human subjects. Therefore, the primary goal of this proposal is to
provide a better understanding of the effect of bariatric surgery-induced weight loss on
insulin action and pancreatic beta cell function.
Inclusion Criteria:
- BMI ≥ 35 kg/m²
- on stable dose of medications for at least 4 weeks before the pre-surgery metabolic
studies
Exclusion Criteria:
- smokes > 7 cigarettes per day
- previous malabsorptive or restrictive intestinal surgery
- pregnant or breastfeeding
- recent history of neoplasia (< 5 years ago)
- have malabsorptive syndromes and inflammatory intestinal disease
- diabetes mellitus
- show signs of oral disease or xerostomia (i.e., dry mouth)
- history of chronic rhinitis
- on medication that might affect metabolism
- severe organ dysfunction
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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