Colorectal Cancer Screening for Cancer Survivors
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 35 - 49 |
| Updated: | 2/2/2018 |
| Start Date: | May 2008 |
| End Date: | January 24, 2018 |
Colorectal Cancer Screening in Cancer Survivors Treated With Radiation Therapy
The risk of colorectal cancer (CRC) is significant among cancer survivors treated with
abdominal radiation therapy (RT). Further, CRC is once of the few cancers for which there is
effective screening. Although some expert groups recommend early CRC screening for patients
with prior abdominal RT, the effectiveness of early screening is unknown. It is also unknown
if radiation-induced CRC passes through a "pre-clinical" phase in which precancerous polyps
are detectable and treatable prior to becoming invasive cancers. This study will evaluate
whether screening will detect pre-invasive colorectal polyps among survivors treated with RT.
abdominal radiation therapy (RT). Further, CRC is once of the few cancers for which there is
effective screening. Although some expert groups recommend early CRC screening for patients
with prior abdominal RT, the effectiveness of early screening is unknown. It is also unknown
if radiation-induced CRC passes through a "pre-clinical" phase in which precancerous polyps
are detectable and treatable prior to becoming invasive cancers. This study will evaluate
whether screening will detect pre-invasive colorectal polyps among survivors treated with RT.
Cancer survivors meeting the COG criteria for CRC screening will undergo colonoscopy and
removal of colorectal polyps. Documentation of polyp number, location and pathologic
characteristics will be made. Clinical data information will also be collected at the time of
patient enrollment.
removal of colorectal polyps. Documentation of polyp number, location and pathologic
characteristics will be made. Clinical data information will also be collected at the time of
patient enrollment.
Inclusion Criteria:
1. Asymptomatic survivors treated with ≥ 25Gy to the abdomen, pelvis or spine, or ≥ 12Gy
total body radiation therapy, or ≥ 12Gy whole abdominal RT.
2. Patients who have passed ≥10 years following RT
3. Patients whose current age is 35-49.
Exclusion Criteria:
1. Patients with signs/symptoms suggestive of CRC or other high-risk features such as:
- Persistent constipation for >2 weeks in the last month
- One or more unexplained episodes of red blood in the stool in the last month
- One or more unexplained episodes of black stool in the last month
- Unexplained pelvic pain in the last month
2. Patients with a history of Crohn's disease or ulcerative colitis
3. Patients already taking part in a colorectal screening program defined as any
colorectal screening (colonoscopy, sigmoidoscopy, fecal occult blood test) within last
5 years.
4. Patients with self-reported history of colorectal polyps.
We found this trial at
2
sites
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