Brain Imaging of Quetiapine Response in Anxious Depression
| Status: | Archived |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | March 2009 |
| End Date: | March 2014 |
The purpose of this study is to find out what parts of the brain have increased or decreased
connectivity when people are depressed and how Seroquel extended release (XR) changes this
connectivity in depressed patients. The genetic samples collected are to look at variation
in a gene (serotonin transporter gene), which affects the functioning of the chemical
serotonin in the brain.
This study will measure the activity and connectivity in different parts of the brain, while
the patients are seeing some pictures, using Magnetic Resonance Imaging (MRI) scan. For
this study three MRI scans will be conducted. One before the patient begins on any
medication, one during the study after 3 weeks of treatment and one after six more weeks of
treatment with seroquel.
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