Investigation of Cisplatin-Related Kidney Toxicity

This study will look for novel biomarkers of kidney injury in patients receiving cisplatin in
patients currently receiving cisplatin.

DNA will be collected both prospectively and retrospectively (from patients that have
previously received cisplatin.

Prospective Analysis Group

Inclusion Criteria:

- Patients about to receive intravenous cisplatin for the first time as part of cancer
chemotherapy.

- Aged 18 years and older.

- Ability to understand and willingness to sign a written consent document.

- Patients may be receiving cisplatin in combination with other chemotherapeutic agents.

- Patients may be receiving cisplatin in the context of another clinical trial.

Exclusion Criteria:

- Prior receipt of cisplatin.

- Patients on dialysis or other renal replacement therapy prior to starting cisplatin.

- Uncontrolled hypo- or hyperthyroidism (patients on chronic stable doses of thyroid
replacement medication are eligible).

Retrospective Analysis Group

Inclusion Criteria:

- Patients that have previously received intravenous cisplatin as part of cancer
chemotherapy.

- Aged 18 years and older.

- Ability to understand and willingness to sign a written consent document.

- Patients that received cisplatin in combination with other chemotherapeutic agents are
eligible.

- Patients that received cisplatin in the context of a clinical trial are eligible.

Exclusion Criteria:

- Unable or unwilling to submit to a one-time blood draw.