TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)



Status:Recruiting
Conditions:Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:20 - Any
Updated:8/10/2018
Start Date:March 2009
End Date:December 2020
Contact:Jochen D Muehlschlegel, MD, MMSc
Email:jmuehlschlegel@partners.org
Phone:617-732-7330

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Trial Summary
Trial Overview
Inclusion Criteria

Whole Genome Expression of Left Ventricular Myocardium During Cardiac Surgery

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in
response to ischemia during cardiopulmonary bypass. To test this, the investigators will be
taking small pieces of heart tissue from patients undergoing heart surgery before and after
this period of ischemia. This will be compared to blood gene expression in blood cells and
analyzed with the patients' genetic profile. This might allow us to assess the amount of
inflammation that occurs when patients are on the heart-lung machine as well as examine the
effects genes have on this critical time period.


Inclusion Criteria:

- Aged greater than 20 years

- Undergoing aortic valve surgery with or without CABG surgery

- Receive and apical vent as part of the surgery

Exclusion Criteria:

- Will not receive an apical left ventricular vent
We found this trial at
1
site
Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Jochen D Muehlschlegel, MD
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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