The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems?
| Status: | Completed |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | November 2009 |
| End Date: | May 2012 |
| Contact: | Jerry L. Lewis, MD |
| Email: | jerry-lewis@uiowa.edu |
| Phone: | 319-384 5630 |
Memantine Augmentation of Electroconvulsive Therapy in Patients With Major Depression
The purpose of this study is to determine whether memantine will enhance the therapeutic of
effect on depression and prevent memory and other cognitive problems caused by ECT.
effect on depression and prevent memory and other cognitive problems caused by ECT.
Patients will be assigned randomly either to a treatment group or a placebo groups. All
patients in both groups will be receiving standard ECT. The treatment group will receive
memantine. All patients will be given a battery of cognitive tests and test of depression
before ECT treatments start, after the 6th ECT treatment and after the completions of ECT.
An analysis will be performed to see if memantine causes any impact on the response to ECT
and prevents memory and cognitive impairment.
patients in both groups will be receiving standard ECT. The treatment group will receive
memantine. All patients will be given a battery of cognitive tests and test of depression
before ECT treatments start, after the 6th ECT treatment and after the completions of ECT.
An analysis will be performed to see if memantine causes any impact on the response to ECT
and prevents memory and cognitive impairment.
Inclusion Criteria:
- Meets criteria for Major Depressive disorder
Exclusion Criteria:
- Neurological disease
- Mental retardation
- Seizure disorder
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