Study of Plerixafor Combined With Cytarabine and Daunorubicin in Patients With Newly Diagnosed Acute Myeloid Leukemia

The purpose of this research study is to determine if plerixafor can make cells more
sensitive to killing by Cytarabine and Daunorubicin, an anti-cancer drug regimen referred to
as "7+3" that is commonly used in treating acute myeloid leukemia (AML). In this study,
plerixafor is used with treatments Cytarabine and Daunorubicin and with and without
granulocyte-colony stimulating factor (GCSF). Subjects will be monitored to see how well
they tolerate the use of these drugs together and how well they work to treat the leukemia.

The purpose of the study is to find the highest dose of plerixafor and/or recommended phase
2 dose that can be given safely with Cytarabine and Daunorubicin and with and without
granulocyte-colony stimulating factor (GCSF).