Alcohol Exposure and Airway Hyperresponsiveness
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | October 2009 |
| End Date: | January 2013 |
Alcohol has well-established consequences in the lung including increased risk for upper
respiratory tract infections, pneumonia and acute respiratory distress syndrome (ARDS).
There have even been a few reports of alcohol-induced asthma. Data from the investigators'
laboratory have established that the airways are specifically impacted by alcohol exposure.
Because the airways are heavily exposed to the vapor phase of alcohol during drinking and
airway motor tone is modulated by cAMP, the investigators speculated that airway bronchial
motor function would be altered in mice fed alcohol. The investigators' preliminary studies
demonstrate that brief alcohol administration significantly attenuates airway
hyperresponsiveness (AHR) in a mouse model. This novel finding has led us to hypothesize
that:
Alcohol exposure modifies airway hyperresponsiveness through a cAMP/NO- dependent mechanism.
respiratory tract infections, pneumonia and acute respiratory distress syndrome (ARDS).
There have even been a few reports of alcohol-induced asthma. Data from the investigators'
laboratory have established that the airways are specifically impacted by alcohol exposure.
Because the airways are heavily exposed to the vapor phase of alcohol during drinking and
airway motor tone is modulated by cAMP, the investigators speculated that airway bronchial
motor function would be altered in mice fed alcohol. The investigators' preliminary studies
demonstrate that brief alcohol administration significantly attenuates airway
hyperresponsiveness (AHR) in a mouse model. This novel finding has led us to hypothesize
that:
Alcohol exposure modifies airway hyperresponsiveness through a cAMP/NO- dependent mechanism.
Inclusion Criteria:
- male
- must be of legal drinking age in the state of Nebraska (≥ 21)
- be between the ages of 21-65
- be non-smokers
- be able to dedicate 3-4 hours on two consecutive days (including waiting at least 2
hours after the alcohol ingestion)
- able to provide informed consent
Exclusion Criteria:
- female
- inability to give informed consent
- any history of lung or allergic disease
- any alcohol intake for the week prior to the experiment
- self-identified history of chronic heavy drinking or alcoholism or psychiatric
disorder
- If an otherwise qualifying participant has previously undocumented or unidentified
asthma as indicated by the baseline methacholine challenge, that subject will be
excluded from the remainder of the study and replaced by another subject
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