Data Collection of Normal Tissue Toxicity for Proton Therapy

As part of your standard of care, you will be examined by your doctor weekly during your
routine proton therapy and then 1-3 more times up to 90 days from the start of treatment and
then at least once a year after that.

Also as part of your standard of care, certain standard laboratory blood and/or urine test
and/or radiologic tests will be done to check if the tumor is under control and to look for
any side effect of the treatment.

If you agree to take part in this study, all of the information collected during your visits
as well as detailed information on the proton treatment plan will be gathered and stored in a
computer for future analysis.

You will fill out quality-of-life questionnaires that should take about 15-20 minutes to
complete.

Inclusion Criteria:

1. All patients scheduled for radiation treatment with protons at UTMDACC are eligible
for this protocol.

2. Patients must be 18 years of age or older (patients under 18 years of age will be
eligible for a similar pediatric protocol)

3. Patients must sign a study-specific consent form prior to study entry. A research
nurse/data coordinator will consent the patient at the earliest clinical appointment
if currently receiving treatment or when treatment begins. The research nurse/data
coordinator has undergone adequate training in the protection of human subjects.

Exclusion Criteria:

1. Patients who are unable or unwilling to attend the required periodic follow-ups either
at M.D.Anderson or at a different site.