Magnetic Resonance Imaging (MRI) in the Assessment of Head and Neck Squamous Cell Carcinoma (HNSCC) Response
| Status: | Terminated |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | October 2011 |
| End Date: | June 2015 |
Pilot Study of DCE-MRI, DW-MRI, and MRS in the Assessment of Head and Neck Cancer Response to Chemo-radiation
The purpose of this study is to see if new techniques of measuring HNSCC tumors with
magnetic resonance imaging (MRI) can help predict how well the tumors will respond to
combined chemotherapy and radiation treatment. The investigators hope to find a reliable
method to determine whether or not a patient's cancer is responding to chemo-radiation early
in their treatment using an MRI, such that that cancer treatments could be tailored to the
individual more effective in the future. The MRI techniques include dynamic
contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted magnetic
resonance imaging (DW-MRI), and magnetic resonance spectroscopy (MRS). Participants will be
subjected to two sessions of MRI scans: one before the initiation of their regular treatment
and the second before their second cycle of chemotherapy. Each scanning session will last
approximately 45 minutes.
magnetic resonance imaging (MRI) can help predict how well the tumors will respond to
combined chemotherapy and radiation treatment. The investigators hope to find a reliable
method to determine whether or not a patient's cancer is responding to chemo-radiation early
in their treatment using an MRI, such that that cancer treatments could be tailored to the
individual more effective in the future. The MRI techniques include dynamic
contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted magnetic
resonance imaging (DW-MRI), and magnetic resonance spectroscopy (MRS). Participants will be
subjected to two sessions of MRI scans: one before the initiation of their regular treatment
and the second before their second cycle of chemotherapy. Each scanning session will last
approximately 45 minutes.
DCE-MRI, DW-MRI, MRS have the potential to measure early cellular changes that occur in
response to successful therapies, such as chemoradiation, and have been demonstrated to be
early predictors not only of therapeutic response, but also of overall survival for other
malignancies. Our long-term goal is to use these imaging techniques to develop non-invasive
functional imaging methodologies that would be better predictors of pathological response
than the current clinical standard.
response to successful therapies, such as chemoradiation, and have been demonstrated to be
early predictors not only of therapeutic response, but also of overall survival for other
malignancies. Our long-term goal is to use these imaging techniques to develop non-invasive
functional imaging methodologies that would be better predictors of pathological response
than the current clinical standard.
Inclusion Criteria:
- Histologically confirmed diagnosis of loco-regionally advanced (stage III or IV)
squamous cell carcinoma of the head and neck (oropharynx, hypopharynx and larynx)
- Age > 18 years
- No prior surgery, chemotherapy or radiation therapy for head and neck cancer
- Scheduled to receive chemoradiation for definitive therapy
Exclusion Criteria:
- Contraindications to MRI (pacemaker, aneurysm clip, mechanical and/or electrical
device or metallic fragment, severe claustrophobia)
- Contraindications to gadolinium
- Severe, active co-morbidity
- Major medical illnesses or psychiatric impairments
- Pregnant or nursing women
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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