Development of a Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients



Status:Completed
Conditions:Other Indications
Therapuetic Areas:Other
Healthy:No
Age Range:30 - 85
Updated:4/21/2016
Start Date:October 2009
End Date:October 2012

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The long-term objective of this research is to develop a non-invasive approach for early
assessment of which patients are at high risk for future development of skeletal muscle
atrophy. The investigators hypothesize that the rate constant for the terminal portion of
the isotope decay curve following ingestion of a single oral dose of
deuterated-3-methylhistidine (D-3MH) provides an accurate measure of this increased risk and
that this rate constant can be measured non-invasively from timed spot urine samples. In
addition, the investigators hypothesize that ingestion of a meat-containing meal will
stimulate synthesis of skeletal muscle proteins to a greater extent than a
non-meat-containing meal.


Inclusion Criteria:

- male

- 30-85 years

- Body Mass Index (BMI) <30 kg/m2

Exclusion Criteria:

- Uncontrolled hypertension

- Glomerular filtration rate less than 60 mL/min/1.73 m2

- History of recurrent gastrointestinal bleeding

- Unable or unwilling to provide informed consent

- Ongoing anti-coagulant therapy
We found this trial at
1
site
301 University Blvd
Galveston, Texas 77555
(409) 772-1011
University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
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from
Galveston, TX
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