Study of Blood and/or Urine Samples From Cancer Patients Receiving Radiation Therapy at the National Cancer Institute
| Status: | Archived |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | November 2002 |
Collection of Peripheral Blood and/or Urine From Patients Undergoing Radiation Therapy
RATIONALE: Studying samples of blood and/or urine in the laboratory from patients receiving
radiation therapy my help doctors learn more about the effects of radiation therapy on
cells. It may also help doctors find better ways to treat the cancer.
PURPOSE: This research study is looking at the effects of radiation therapy in blood and/or
urine samples from patients receiving radiation therapy for cancer.
OBJECTIVES:
- Acquire peripheral blood and/or urine samples from patients receiving radiotherapy in
the NCI Radiation Oncology Branch.
OUTLINE: Samples of blood and/or urine are obtained from patients before, during, and after
radiotherapy. Samples are analyzed for expression of genes in white blood cells via cDNA
microarray analysis and radiation damage in red blood cells via flow cytometry, VEGF levels
in serum and urine via ELISA, profiles of matrix metalloproteinases (MMPs) in urine, and
changes in hormones levels in blood and urine. Samples may be stored for future research
studies.
PROJECTED ACCRUAL: A total of 300 patients will be accrued for this study.
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National Cancer Institute (NCI) The National Cancer Institute (NCI) is part of the National Institutes...
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