Glucose and Lipid Metabolism in Adolescents
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 13 - 17 |
| Updated: | 4/2/2016 |
| Start Date: | February 2004 |
| End Date: | December 2011 |
| Contact: | Agneta L Sunehag, M.D., Ph.D. |
| Email: | asunehag@bcm.tmc.edu |
| Phone: | 713 798 6725 |
A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat
accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary
Hispanic adolescents.
accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary
Hispanic adolescents.
Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week
at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise
program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen
(identical on both study occasions); metabolic studies (identical on both study occasions)
including 24h calorimetry, measurements of glucose and lipid metabolism and insulin
sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes
and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and
visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to
specifically determine the effects of exercise, there is no intent of weight loss. The
subjects are weighed twice a week to assure weight stability.
at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise
program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen
(identical on both study occasions); metabolic studies (identical on both study occasions)
including 24h calorimetry, measurements of glucose and lipid metabolism and insulin
sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes
and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and
visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to
specifically determine the effects of exercise, there is no intent of weight loss. The
subjects are weighed twice a week to assure weight stability.
Inclusion Criteria:
- Healthy
- No medication
- Sedentary
- No first degree relative with diabetes,
- Hispanic
- BMI >30 or <25 kg/m2.
Exclusion Criteria:
- Any medication including birth control pills
- Performing more than >45 min of moderate to light physical activity/week
- Chronic illness
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