Identifying Changes in Blood (Potential Biomarkers) in Individuals With Drug-Induced Liver Injury
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/2/2016 |
| Start Date: | September 2009 |
| End Date: | December 2013 |
| Contact: | Paul B Watkins, MD |
| Email: | paul_watkins@med.unc.edu |
| Phone: | 919-226-3140 |
Identification of New Biomarkers of Drug Induced Liver Injury
The purpose of this study is to try to develop new blood tests that may help doctors
identify if a drug is hurting a person's liver.
identify if a drug is hurting a person's liver.
Our hypothesis is that there are liver-specific particles, called mRNA, that are
identifiable in a person's blood sample during liver injury caused by some drugs. The
purpose of this study is to try to develop new blood tests that may help doctors identify if
a drug is hurting a person's liver, perhaps early in the process before significant injury
or illness have occurred.
identifiable in a person's blood sample during liver injury caused by some drugs. The
purpose of this study is to try to develop new blood tests that may help doctors identify if
a drug is hurting a person's liver, perhaps early in the process before significant injury
or illness have occurred.
Inclusion Criteria:
- ALT > 200 IU/L at presentation to UNC Hospitals
- Drug induced liver injury considered likely by admitting medical staff
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