Pemetrexed Disodium and Carboplatin in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

PRIMARY OBJECTIVES:

I. To evaluate the response rate of combination pemetrexed (pemetrexed disodium) (Alimta)
and carboplatin (Paraplatin) in recurrent ovarian, primary peritoneal, and fallopian tube
carcinoma.

SECONDARY OBJECTIVES:

I. To evaluate the progression free interval, overall survival, and adverse effects among
patients receiving this drug combination.

OUTLINE:

Patients receive pemetrexed disodium intravenously (IV) over 8-15 minutes and carboplatin IV
over 30-60 minutes on day 1. Treatment repeats every 21 days for at least 6 courses in the
absence of disease progression or unacceptable toxicity.

Inclusion Criteria:

- Patients must have a histopathologically confirmed diagnosis of epithelial ovarian,
primary peritoneal, or fallopian tube carcinoma

- Patients must have received at least 1 prior platinum and taxane based chemotherapy
regimen; patients may have failed no more than 2 prior chemotherapy regimens

- Patients must have "platinum sensitive" disease, which will be defined as those
patients with relapsed disease who had an initial complete remission, and relapsed
more than 6 months after completion of initial platinum based chemotherapy

- Recurrent disease must be confirmed by:

- Bidimensionally measurable disease which can be measured by physical examination
or by means of medical imaging techniques (measurable disease)

- Measurable disease is defined as at least one lesion that can be accurately
measured in at least one dimension (longest dimension to be recorded); each
lesion must be >= 2.0 cm when measured by conventional techniques,
including palpation, x-ray, computed tomography (CT), and magnetic
resonance imaging (MRI), or >= 1.0 cm when measured by spiral CT; all
measurable lesions up to a maximum of 5 lesions per organ and 10 lesions in
total representative of all involved organs should be identified as target
lesions and will be recorded and measured at baseline; all baseline
evaluations of disease status should be performed as close as possible to
the start of treatment and never more than 4 weeks before the beginning of
treatment

- Target lesions should be selected on the basis of their size (lesions with
the longest dimension, LD) and their suitability for accurate repetitive
measurements by one consistent method of assessment (either clinically or
by imaging techniques); a sum of LD for all target lesions will be
calculated and reported as the baseline sum LD; the baseline sum LD will be
used as reference to further characterize the objective tumor response of
the measurable dimension of the disease; all other lesions (or sites of
disease) should be identified as non-target lesions and should also be
recorded at baseline OR

- Two confirmed serum cancer antigen-125 (CA-125) levels greater than or equal to
70 u/ml (or 2 x upper limit of normal) separated by 1 week and obtained within 4
weeks prior to entry to the study (evaluable disease)

- Patients must not have had other myelosuppressive therapy within four weeks of
initiating pemetrexed/ carboplatin therapy

- Patients must have recovered from effects of recent surgery

- Patients must have a Gynecologic Oncology Group (GOG) performance status of 0, 1, or
2

- White blood cell (WBC) greater than or equal to 3,000/ul

- Platelet count greater or equal to 100,000/ul

- Neutrophil count greater or equal to 1,500/ul

- Creatinine clearance >= 45 ml/min (estimated creatinine clearance by Cockcroft-Gault
equation acceptable)

- Total bilirubin =< to 1.5 mg/dL

- Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamate pyruvate
transaminase (SGPT) =< three times the upper normal institutional limits; if patient
has known hepatic metastases, patients may be enrolled if liver function test is =<
five times the upper normal institutional limits

- Alkaline phosphatase =< three times the upper normal institutional limits; if patient
has known hepatic metastases, patients may be enrolled if liver function test is =<
five times the upper normal institutional limits

- Patient must have signed informed consent

- Patients must be willing to take the dexamethasone, folic acid and vitamin B12
supplementation as indicated in the protocol to reduce adverse drug toxicity

- Patients must be willing to interrupt aspirin and other nonsteroidal
anti-inflammatory drugs (NSAID) intake for 2 days before, day of, and 2 days after
each chemotherapy treatment; low dose 80 mg aspirin and cyclooxygenase-2 (Cox-2)
inhibitors are excluded from this restriction; if concomitant administration of an
NSAID is necessary, patients should be monitored closely

- Patients must have a life expectancy of greater than 12 weeks

- Patients may not have concurrent or previous invasive malignancies, with the
exception of non-melanoma skin cancer or no evidence of recurrence of previous
malignancy within the last 5 years

- Patients must have a current exam, blood work and any clinically indicated imaging
studies within 4 weeks prior to study enrollment

- Baseline folate and homocysteine blood levels

- The ability to interrupt NSAIDS 2 days before (5 days for long-acting NSAIDs), the
day of, and 2 days following administration of Alimta

- The ability to take folic acid, vitamin B12, and dexamethasone according to protocol

Exclusion Criteria:

- Patients who have had more than two prior chemotherapeutic regimens

- Patients who have had prior treatment with pemetrexed

- Patients with a GOG performance status of 3 or 4

- Patients with >= grade 2 neuropathy

- Patients who have received external beam whole pelvic or whole abdominal radiation
treatment (>= 4500 centigray [cGy]) which would limit vascular capacity and reduce
adequate drug delivery

- Patients with evidence of recurrence from another malignancy within the previous five
years

- Patients with a concomitant malignancy other than squamous cell skin cancer

- Patients with uncontrolled intercurrent illness including, but not limited to,
ongoing or active infection, unstable angina pectoris, or psychiatric illness/social
situations that would limit compliance with study requirements

- Patients who have received an investigational drug within the last 30 days that has
not received regulatory approval

- Presence of third space fluid which cannot be controlled by drainage; for patients
who develop or have baseline clinically significant pleural or peritoneal effusions
(on the basis of symptoms or clinical examination) before or during initiation of
Alimta therapy, consideration should be given to draining the effusion prior to
dosing; however, if, in the investigator's opinion, the effusion represents
progression of disease, the patient should be discontinued from study therapy