Natural History of Levodopa-Induced Dyskinesia (LID)
| Status: | Withdrawn |
|---|---|
| Conditions: | Parkinsons Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 21 - 100 |
| Updated: | 4/21/2016 |
| Start Date: | December 2010 |
| End Date: | December 2020 |
Determining the Natural History of Levodopa-Induced Dyskinesia (LID)
Levodopa is the main drug treatment for Parkinson's disease. Levodopa can cause unwanted and
uncontrolled movements called dyskinesias (LID). The severity of these movements can range
from subtle to extremely debilitating. These movements may or may not interfere with normal
activities such as putting on a coat or brushing ones teeth. Current estimates of the
occurrence rate of LID range from 12 % to 100% after one year of levodopa treatment. These
estimates used reporting mechanisms such as self-report and doctor-reported. These reporting
mechanisms are not reliable. We will use an objective measure of dyskinesia in the first 5
years of treatment for Parkinson's disease. The purpose of this protocol is to use an
objective measure to estimate dyskinesia onset.
uncontrolled movements called dyskinesias (LID). The severity of these movements can range
from subtle to extremely debilitating. These movements may or may not interfere with normal
activities such as putting on a coat or brushing ones teeth. Current estimates of the
occurrence rate of LID range from 12 % to 100% after one year of levodopa treatment. These
estimates used reporting mechanisms such as self-report and doctor-reported. These reporting
mechanisms are not reliable. We will use an objective measure of dyskinesia in the first 5
years of treatment for Parkinson's disease. The purpose of this protocol is to use an
objective measure to estimate dyskinesia onset.
Nearly all Parkinson's disease (PD) patients eventually develop abnormal and unwanted
movements (dyskinesias; LID) caused by the gold standard treatment, Levodopa. The severity
of these movements can range from subtle to extremely debilitating and may or may not
interfere with normal activities such as putting on a coat or brushing ones teeth. Current
estimates of the prevalence of LID widely range from 12 % to 100% affected after one year.
The purpose of this study is to estimate the median onset time of levodopa induced
dyskinesia in newly treated Parkinson's disease patients. All participants will complete
seven overnight visits at the OCTRI Inpatient unit over 5 years. During the next day,
participants will complete a mental task while standing on a force plate for one minute
every half hour until the end of the study. A levodopa IV infusion will occur from 0900 to
1100.
movements (dyskinesias; LID) caused by the gold standard treatment, Levodopa. The severity
of these movements can range from subtle to extremely debilitating and may or may not
interfere with normal activities such as putting on a coat or brushing ones teeth. Current
estimates of the prevalence of LID widely range from 12 % to 100% affected after one year.
The purpose of this study is to estimate the median onset time of levodopa induced
dyskinesia in newly treated Parkinson's disease patients. All participants will complete
seven overnight visits at the OCTRI Inpatient unit over 5 years. During the next day,
participants will complete a mental task while standing on a force plate for one minute
every half hour until the end of the study. A levodopa IV infusion will occur from 0900 to
1100.
Inclusion Criteria:
- Diagnosis of Parkinson's disease
- At least 21 years of age
- Levodopa treatment that will be orally initiated no more than 1 month after the
screening visit for the study.
Exclusion Criteria:
- Unable to stand for 1 minute intervals
- Sensory deficits in the feet
- Significant cognitive impairment
- Unstable medical or psychiatric conditions (including hallucinations)
- History of dopamine receptor blocking medications (Haldol, Orap, Zyprexa)
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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