Outcomes of Oncology Therapy in the Elderly: Trajectory of Functional Decline and Correlates of Change
| Status: | Archived |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | November 2009 |
The proposed project will document the degree of function decline, assess the relationship
between function and cancer- related symptoms and evaluate relationships between function
and quality of life. Participants are evaluated before therapy, after therapy and again 3
months post therapy to evaluate functional change. Knowledge gained will help us plan
interventions around the time of cancer therapy to help older adults preserve or improve
function.
The study looks at functional change of elderly cancer patients. Approximately 52 cancer
patients age 65 or older will be asked to participate. Cancer patients asked to participate
will be receiving cancer therapy with the intention of providing a cure. Functional change
will be assessed from the time of diagnosis, through therapy to the early post therapy time
frame. A comprehensive model explaining reasons for function change is used as the
framework for choosing variables to measure. Components of function that will be measured
include a 6 minute walk test, lower extremity muscle strength, a Short Physical Performance
Battery assessing function of legs and a test that simulates typical household activities.
Surveys will be used to subjects own assessment of their activity and function. The four
most common cancer-related side effects will be measured and include fatigue, sleep
impairment, shortness of breath and pain. Some markers in the blood may be abnormal and be
related to declines in function. They will also be measured. Differences in function over
time will be determined and relationships between function, cancer-related side effects and
quality of life will be assessed.
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