Alfentanil: Simultaneous Testing Pilot

Inclusion Criteria:

- Male or non-pregnant female, 18-40 yr. old

- Good general health with no remarkable medical conditions such as liver, kidney,
heart, or lung failure

- BMI between 20-33

- Provide informed consent

Exclusion Criteria:

- Known history of liver or kidney disease

- Use of prescription or non prescription medications, herbals or foods known to be
metabolized by or affect CYP3A (including oral birth control medications)

- Females who are pregnant or nursing

- Known history of drug or alcohol addiction (prior or present addiction or treatment
for addiction)

- Direct physical access to and routine handling of addicting drugs in the regular
course of duty (this is a routine exclusion from studies of drugs with addiction
potential).

- History of bradycardia

- Respiratory rate <10

- History of significant pulmonary disease

- History of pre-existing medical condition predisposing to respiratory depression

- Systolic blood pressure <100 mgHg and diastolic blood pressure <70mmHg