Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:7/16/2013
Start Date:December 2009
End Date:June 2013
Contact:Pfizer CT.gov Call Center
Phone:1-800-718-1021

Use our guide to learn which trials are right for you!

Randomized, Parallel, Double-Blind, Placebo-Controlled Trial To Evaluate The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis On A Stable Background Of Methotrexate


This study is designed to evaluate the safety and efficacy of a dose and dosage regimen of
SBI-087 in seropositive patients with active Rheumatoid Arthritis, who are on a stable dose
of methotrexate.


Inclusion Criteria:

- Meets the American College of Rheumatology (ACR) 1987 revised criteria for
classification of Rheumatoid Arthritis (RA) for at least 6 months prior to screening

- Active RA as defined by >= 5 swollen and >= 5 tender joints (28-joint count) and at
least 1 of the following: C-reactive protein >= 10 mg/L or Erythrocyte Sedimentation
Rate >= 28 mm/h

- Must be seropositive as defined by a documented history of rheumatoid factor (RF) or
anti-cyclic citrullinated peptide (anti-CCP) positivity

- Must be receiving a stable route and dose of methotrexate (up to 25 mg weekly)

Exclusion Criteria:

- Any significant health problem other than rheumatoid arthritis

- Any clinically significant laboratory abnormalities

- Any prior use of B cell-depleting therapy
We found this trial at
16
sites
Beckley, West Virginia 25801
?
mi
from
Beckley, WV
Click here to add this to my saved trials
Akron, Ohio 44314
?
mi
from
Akron, OH
Click here to add this to my saved trials
Albuquerque, New Mexico 87108
?
mi
from
Albuquerque, NM
Click here to add this to my saved trials
Anderson, South Carolina 29621
?
mi
from
Anderson, SC
Click here to add this to my saved trials
Atlantis, Florida 33462
?
mi
from
Atlantis, FL
Click here to add this to my saved trials
Bloomingdale, Illinois 60108
?
mi
from
Bloomingdale, IL
Click here to add this to my saved trials
Boston, Massachusetts 02115
?
mi
from
Boston, MA
Click here to add this to my saved trials
Bristol, Tennessee 37620
?
mi
from
Bristol, TN
Click here to add this to my saved trials
Detroit, Michigan 48202
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Fargo, North Dakota 58104
?
mi
from
Fargo, ND
Click here to add this to my saved trials
Gilbert, Arizona 85234
?
mi
from
Gilbert, AZ
Click here to add this to my saved trials
Lewes, Delaware 19958
?
mi
from
Lewes, DE
Click here to add this to my saved trials
Los Angeles, California 90027
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Norman, Oklahoma 73069
?
mi
from
Norman, OK
Click here to add this to my saved trials
Rochester, New York 14642
?
mi
from
Rochester, NY
Click here to add this to my saved trials
Seattle, Washington 98166
?
mi
from
Seattle, WA
Click here to add this to my saved trials