An Adhesion Reduction Plan in the Management of the Surgical Open Abdomen
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | January 2011 |
| End Date: | December 2011 |
| Contact: | William C. Chiu, M.D. |
| Email: | wchiu@umm.edu |
| Phone: | 410-328-1205 |
Effect of an Adhesion Reduction Plan on Enteric Adhesions, Obstruction, and Fistulae in the Management of the Surgical Open Abdomen: A Prospective, Randomized Clinical Trial in Trauma and Emergency General Surgery
The purpose of this study is to determine whether an adhesion reduction plan, consisting of
early adhesion prevention and application of a bioresorbable membrane is effective in
reducing the severity of adhesions and the incidence of complications in managing the open
abdomen in trauma and emergency general surgery.
early adhesion prevention and application of a bioresorbable membrane is effective in
reducing the severity of adhesions and the incidence of complications in managing the open
abdomen in trauma and emergency general surgery.
Adhesions are a common consequence of abdominal surgery. Trauma and emergency general
surgery patients may require an open abdomen and undergo a series of abdominal operations,
which may be increasingly complicated by the presence of adhesions. Adhesions appear soon
after the initial operation and gradually mature within days. The effects of adhesion
development on subsequent surgery may include: increased procedure time; difficulty
differentiating, exposing, and accessing tissue planes; and increased risk of inadvertent
enterotomy. Complications of adhesions include enteric obstruction and enterocutaneous
fistulae. This study will determine whether an adhesion reduction plan, consisting of early
adhesion prevention and application of a bioresorbable membrane is effective in reducing the
extent and severity of adhesions and the incidence of complications in managing the open
abdomen in trauma and emergency general surgery.
surgery patients may require an open abdomen and undergo a series of abdominal operations,
which may be increasingly complicated by the presence of adhesions. Adhesions appear soon
after the initial operation and gradually mature within days. The effects of adhesion
development on subsequent surgery may include: increased procedure time; difficulty
differentiating, exposing, and accessing tissue planes; and increased risk of inadvertent
enterotomy. Complications of adhesions include enteric obstruction and enterocutaneous
fistulae. This study will determine whether an adhesion reduction plan, consisting of early
adhesion prevention and application of a bioresorbable membrane is effective in reducing the
extent and severity of adhesions and the incidence of complications in managing the open
abdomen in trauma and emergency general surgery.
Inclusion Criteria:
- Trauma patients with open abdomen after initial laparotomy
- Emergency surgery patients with open abdomen after initial laparotomy
- Able to obtain consent from patient or LAR before any research initiated
Exclusion Criteria:
- Seprafilm application at initial laparotomy
- Patient is a prisoner
- Inability to obtain informed consent
- Consentable person does not speak English
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University of Maryland Medical Center Founded in 1823 as the Baltimore Infirmary, the University of...
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