Cytomegalovirus (CMV) Infection in Amniotic Fluid

CMV infection in adults with a normal immune system is rarely a serious event. Once a person
has been infected with CMV, they may have recurrences (relapses) of the infection. If a
mother is infected with the virus or relapses during pregnancy, her fetus may be at risk for
infection. Unlike infection in adults, congenital infection may result in serious
complications (congenital infection). The effects of fetal infection with CMV are well
understood and many efforts have been made to potentially reduce the risk of congenital
infection. However, the effect of CMV infection on the pregnancy itself (when the fetus is
not affected by CMV) is less understood.

The incidence of CMV detection in amniotic fluid collected in the second trimester is
thought to be low. However, the association between detection of CMV infection in the second
trimester and ultimate pregnancy outcome is poorly described.

In this study, we plan to determine if CMV detection in amniotic fluid collected in the
second trimester is associated with pregnancy complications.

Inclusion Criteria:

- Women who deliver at term without pregnancy complications

- Women who deliver (preterm, less than 37 weeks of gestation) as a result of
spontaneous preterm labor

- Women whose pregnancies are complicated by severe preeclampsia

Exclusion Criteria:

- Women with multi-gestational pregnancies, or whose pregnancies are complicated by a
congenital malformation or chromosomal abnormality

- Women who have a medical history of hypertension (high blood pressure), diabetes, or
severe renal (kidney) disease