Internal Monitoring of Eye Movement in Schizophrenia
| Status: | Terminated |
|---|---|
| Conditions: | Schizophrenia |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/8/2017 |
| Start Date: | November 2, 2009 |
| End Date: | August 16, 2016 |
Background:
- Researchers are studying how humans are able to move our eyes to a remembered region
even when the target has disappeared. The ability to do this suggests that the brain can
keep track of where the eyes have looked, without an external target for continued
reference. This is called corollary discharge.
- Other research has indicated that patients with schizophrenia might have difficulty
monitoring their eye movements. The corollary discharge process may be defective in
patients with schizophrenia, and perhaps delayed in time. Researchers have developed a
test to examine this possibility in the hope of learning more about schizophrenia and
eye movement.
Objectives:
- To assess whether there is a defect in internal monitoring of eye movements in patients
with schizophrenia.
Eligibility:
- Individuals over 18 years of age who are able to give informed consent and are able to
concentrate on a 20-minute task that involves following projected targets and moving
their eyes to remembered locations.
- Individuals with schizophrenia will be recruited from an ongoing NIH protocol studying
schizophrenia.
- In addition healthy will be recruited for this protocol.
Design:
- Researchers will check participants' vision in each eye, and ask them to sit at a
machine that measures eye movement in order to complete research tasks. Researchers will
monitor participants ability to complete these tasks.
- The first task involves simply following a target that jumps to different parts of the
screen.
- The second is a 2-step task, in which a participant is asked to look at two separate
light targets and then look at the remembered target positions when the lights are off.
- This protocol does not provide treatment. Participants will remain under the care of
their own physicians during participation in this protocol.
- Researchers are studying how humans are able to move our eyes to a remembered region
even when the target has disappeared. The ability to do this suggests that the brain can
keep track of where the eyes have looked, without an external target for continued
reference. This is called corollary discharge.
- Other research has indicated that patients with schizophrenia might have difficulty
monitoring their eye movements. The corollary discharge process may be defective in
patients with schizophrenia, and perhaps delayed in time. Researchers have developed a
test to examine this possibility in the hope of learning more about schizophrenia and
eye movement.
Objectives:
- To assess whether there is a defect in internal monitoring of eye movements in patients
with schizophrenia.
Eligibility:
- Individuals over 18 years of age who are able to give informed consent and are able to
concentrate on a 20-minute task that involves following projected targets and moving
their eyes to remembered locations.
- Individuals with schizophrenia will be recruited from an ongoing NIH protocol studying
schizophrenia.
- In addition healthy will be recruited for this protocol.
Design:
- Researchers will check participants' vision in each eye, and ask them to sit at a
machine that measures eye movement in order to complete research tasks. Researchers will
monitor participants ability to complete these tasks.
- The first task involves simply following a target that jumps to different parts of the
screen.
- The second is a 2-step task, in which a participant is asked to look at two separate
light targets and then look at the remembered target positions when the lights are off.
- This protocol does not provide treatment. Participants will remain under the care of
their own physicians during participation in this protocol.
OBJECTIVE:
To study if there is a defect in internal monitoring of eye movements in patients with
schizophrenia.
STUDY POPULATION:
Patients with schizophrenia and normal controls.
DESIGN:
Patients and controls will be asked to follow targets to remembered locations and their eye
movements will be monitored.
OUTCOME MEASURES:
Eye movements will be examined for evidence of internal monitoring (corollary discharge)
defects which would result in mislocalizing remembered targets.
To study if there is a defect in internal monitoring of eye movements in patients with
schizophrenia.
STUDY POPULATION:
Patients with schizophrenia and normal controls.
DESIGN:
Patients and controls will be asked to follow targets to remembered locations and their eye
movements will be monitored.
OUTCOME MEASURES:
Eye movements will be examined for evidence of internal monitoring (corollary discharge)
defects which would result in mislocalizing remembered targets.
- INCLUSION CRITERIA:
1. Adult subjects over 18 years of age who are able to give informed consent and are
able to concentrate on a task for 20 minutes which involves following projected
targets and moving their eyes to remembered locations.
EXCLUSION CRITERIA:
1. Large refractive error requiring strong glasses. Glasses may interfere with the video
eye movement recording system. However, participants may wear contact lenses. Subjects
with a history of eye disease affecting vision or eye movements will also be excluded.
2. Participants with guardians will be excluded.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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