Coagulation Factors, Cytokines and Tissue Injury Markers in Sepsis
| Status: | Archived |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | October 2009 |
| End Date: | September 2011 |
Temporal Behavior of Coagulation Factors,Cytokines and Tissue Injury Markers in Sepsis: Validation of Extracellular Histones
In an effort to better understand the interaction between the different mediators, the
investigators propose to examine the time course of mediators, the indexes of organ injury
and the coagulation cascade.
All patients admitted to the ICU (Including VA Medical Center, University Hospital and
Presbyterian hospital) will be screened for enrollment in the study. Patients who have the
diagnosis of sepsis will be asked to volunteer. We will match sepsis patients with other ICU
patients without the diagnosis of sepsis. The latter will also be asked to volunteer.
Patients will be stratified into three groups:
- Sepsis
- SIRS of non-septic origin
- Other ICU patients
Routine laboratory data and clinical data (see flow sheet) will be collected. The plasma or
serum will be frozen separately until the target number of patients is met. Measurements of
inflammatory mediators and other cytokines/injury markers will be carried out at that point.
We found this trial at
2
sites
Click here to add this to my saved trials
Click here to add this to my saved trials