The Effect of Weight on Vitamin D Dose Response
| Status: | Archived |
|---|---|
| Conditions: | Obesity Weight Loss, Other Indications, Gastrointestinal |
| Therapuetic Areas: | Endocrinology, Gastroenterology, Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | November 2009 |
| End Date: | April 2011 |
Vitamin D3 is a vitamin that is an essential component of biological regulating systems in
humans. Sun exposure is the predominant source of vitamin D3. Previous research has shown
that vitamin D3 deficiency is common worldwide. It is especially common in northern
countries with long winters due to inadequate sun exposure during winter. In the US, an
estimated 36% to 57% of healthy middle-aged to elderly adults have vitamin D3 deficiency.
Current research indicates that obesity is associated with a low vitamin D3 level.
Obesity is a known risk factor for vitamin D deficiency. Adequate levels of vitamin D are
important, not only for bone health, but appear to be important for prevention of certain
autoimmune diseases, infections and cancers. Current FDA recommendations for vitamin D
intake do not differentiate between lean and obese people. There are no published studies
indicating if the 25(OH)D response to a given daily dose of vitamin D is any less in an
obese person than a normal weight person. The purpose of this study is to characterize the
quantitative relationship between steady state cholecalciferol input and the resulting serum
25 (OH)D concentration in obese subjects. Data obtained in this study will be compared to
published normative data for non-obese subjects. Recommendations will be provided for
optimal treatment of vitamin D deficiency in obese men and women.
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