A Trial of Antenatal Treatment of Alloimmune Thrombocytopenia
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies, Hematology |
| Therapuetic Areas: | Hematology, Reproductive |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 11/9/2018 |
| Start Date: | April 2001 |
| End Date: | June 30, 2015 |
A Randomized Multicenter Trial of Antenatal Treatment of Alloimmune Thrombocytopenia
The purposes of this study are to provide medical management by giving treatment to the
mother that will bring up the fetal platelet count and to minimize the number of invasive
procedures to the fetus (which may result in serious fetal injuries).
mother that will bring up the fetal platelet count and to minimize the number of invasive
procedures to the fetus (which may result in serious fetal injuries).
Inclusion Criteria:
Pregnant women are eligible for inclusion into the Very High Risk Group if they:
- are PLA-1 (platelet antigen A1) negative and have known platelet incompatibility with
their fetus
- have had a previous child who suffered an antenatal hemorrhage prior to 28 weeks
gestation (as best as could be estimated)
- are less than 19 weeks gestation
Pregnant women are eligible for inclusion into the High Risk Group if they:
- are PLA-1 negative and have known platelet incompatibility with the fetus
- have had a previous child who suffered an antenatal hemorrhage after 28 weeks
gestation (as best as could be estimated)
- are between 12-30 weeks gestation
Pregnant women are eligible for inclusion into the Standard Risk Group if they:
- are PLA-1 negative and have known platelet incompatibility with the fetus
- have not had a previous child who suffered an antenatal hemorrhage
- are between 20-30 weeks gestation
Exclusion Criteria:
Women are not eligible for inclusion into the Very High Risk Group if they:
- have had a previous child who suffered an antenatal hemorrhage after 28 weeks
gestation
- are greater than 19 weeks gestation
Women are not eligible for inclusion into the High Risk Group if they:
- have had a previous child who suffered an antenatal hemorrhage prior to 28 weeks
gestation
- are greater than 30 weeks gestation
Women are not eligible for inclusion into the Standard Risk Group if they:
- have had a previous child who suffered an antenatal hemorrhage
- are greater than 30 weeks gestation
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