Positron Emission Tomography in Monitoring Treatment Response in Women With Newly Diagnosed Breast Cancer
| Status: | Archived |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | March 2009 |
| End Date: | March 2011 |
Monitoring Treatment Response in Women With Breast Cancer Utilizing FLT-PET/CT
This study will investigate the sensitivity and specificity of FLT-PET/CT in primary breast
cancer detection and in the use of FLT-PET in monitoring how well a breast tumor respond to
treatment. We will compare this technique with other imaging modalities as well as with
tissue collection (during a biopsy). We will recruit women with a newly diagnosed invasive
breast cancer, who are able to tolerate undergoing a PET/CT (possibly two scans) scan,
Our overall goal is to use this clinical trial as a platform to validate fibroblast
activation protein (FAP) as a biomarker for the tumor microenvironment and to explore the
dynamic interaction between proliferating tumor cells and the tumor microenvironment. Our
long term goal is to develop new drugs that will target the tumor microenvironment as novel
therapeutic and chemoprevention strategies.
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